TY - BOOK AU - Doran, Pauline M TI - Bioprocess Engineering Principles SN - 9789381269831 U1 - 660.63 DOR-B PY - 2013/// CY - London PB - Elsevier KW - Chemical engineering,Bioprocess N1 - Table of Contents Preface to the Second Edition Part 1 Introduction Chapter 1. Bioprocess Development 1.1 Steps in Bioprocess Development: A Typical New Product from Recombinant DNA 1.2 A Quantitative Approach Chapter 2. Introduction to Engineering Calculations 2.1 Physical Variables, Dimensions, and Units 2.2 Units 2.3 Force and Weight 2.4 Measurement Conventions 2.5 Standard Conditions and Ideal Gases 2.6 Physical and Chemical Property Data 2.7 Stoichiometry 2.8 Methods for Checking and Estimating Results Summary of Chapter 2 References Suggestions for Further Reading Chapter 3. Presentation and Analysis of Data 3.1 Errors in Data and Calculations 3.2 Presentation of Experimental Data 3.3 Data Analysis 3.4 Graph Paper with Logarithmic Coordinates 3.5 General Procedures for Plotting Data 3.6 Process Flow Diagrams Summary of Chapter 3 References Suggestions for Further Reading Part 2 Material and Energy Balances Chapter 4. Material Balances 4.1 Thermodynamic Preliminaries 4.2 Law of Conservation of Mass 4.3 Procedure for Material Balance Calculations 4.4 Material Balance Worked Examples 4.5 Material Balances with Recycle, Bypass, and Purge Streams 4.6 Stoichiometry of Cell Growth and Product Formation Summary of Chapter 4 References Suggestions for Further Reading Chapter 5. Energy Balances 5.1 Basic Energy Concepts 5.2 General Energy Balance Equations 5.3 Enthalpy Calculation Procedures 5.4 Enthalpy Change in Nonreactive Processes 5.5 Steam Tables 5.6 Procedure for Energy Balance Calculations without Reaction 5.7 Energy Balance Worked Examples without Reaction 5.8 Enthalpy Change Due to Reaction 5.9 Heat of Reaction for Processes with Biomass Production 5.10 Energy Balance Equation for Cell Culture 5.11 Cell Culture Energy Balance Worked Examples Summary of Chapter 5 References Suggestions for Further Reading Chapter 6. Unsteady-State Material and Energy Balances 6.1 Unsteady-State Material Balance Equations 6.2 Unsteady-State Energy Balance Equations 6.3 Solving Differential Equations 6.4 Solving Unsteady-State Mass Balances 6.5 Solving Unsteady-State Energy Balances Summary of Chapter 6 References Suggestions for Further Reading Part 3 Physical Processes Chapter 7. Fluid Flow 7.1 Classification of Fluids 7.2 Fluids in Motion 7.3 Viscosity 7.4 Momentum Transfer 7.5 Non-Newtonian Fluids 7.6 Viscosity Measurement 7.7 Rheological Properties of Fermentation Broths 7.8 Factors Affecting Broth Viscosity 7.9 Turbulence Summary of Chapter 7 References Suggestions for Further Reading Chapter 8. Mixing 8.1 Functions of Mixing 8.2 Mixing Equipment 8.3 Flow Patterns in Stirred Tanks 8.4 Impellers 8.5 Stirrer Power Requirements 8.6 Power Input by Gassing 8.7 Impeller Pumping Capacity 8.8 Suspension of Solids 8.9 Mechanisms of Mixing 8.10 Assessing Mixing Effectiveness 8.11 Scale-Up of Mixing Systems 8.12 Improving Mixing in Fermenters 8.13 Multiple Impellers 8.14 Retrofitting 8.15 Effect of Rheological Properties on Mixing 8.16 Role of Shear in Stirred Fermenters Summary of Chapter 8 References Suggestions for Further Reading Chapter 9. Heat Transfer 9.1 Heat Transfer Equipment 9.2 Mechanisms of Heat Transfer 9.3 Conduction 9.4 Heat Transfer between Fluids 9.5 Design Equations for Heat Transfer Systems 9.6 Application of the Design Equations 9.7 Hydrodynamic Considerations with Cooling Coils Summary of Chapter 9 References Suggestions for Further Reading Chapter 10. Mass Transfer 10.1 Molecular Diffusion 10.2 Role of Diffusion in Bioprocessing 10.3 Film Theory 10.4 Convective Mass Transfer 10.5 Oxygen Uptake in Cell Cultures 10.6 Factors Affecting Oxygen Transfer in Fermenters 10.7 Measuring Dissolved Oxygen Concentration 10.8 Estimating Oxygen Solubility 10.9 Mass Transfer Correlations for Oxygen Transfer 10.10 Measurement of kLa 10.11 Measurement of the Specific Oxygen Uptake Rate, qO 10.12 Practical Aspects of Oxygen Transfer in Large Fermenters 10.13 Alternative Methods for Oxygenation without Sparging 10.14 Oxygen Transfer in Shake Flasks Summary of Chapter 10 References Suggestions for Further Reading Chapter 11. Unit Operations 11.1 Overview of Downstream Processing 11.2 Overview of Cell Removal Operations 11.3 Filtration 11.4 Centrifugation 11.5 Cell Disruption 11.6 The Ideal Stage Concept 11.7 Aqueous Two-Phase Liquid Extraction 11.8 Precipitation 11.9 Adsorption 11.10 Membrane Filtration 11.11 Chromatography 11.12 Crystallisation 11.13 Drying Summary of Chapter 11 References Suggestions for Further Reading Part 4 Reactions and Reactors Chapter 12. Homogeneous Reactions 12.1 Basic Reaction Theory 12.2 Calculation of Reaction Rates from Experimental Data 12.3 General Reaction Kinetics for Biological Systems 12.4 Determining Enzyme Kinetic Constants from Batch Data 12.5 Regulation of Enzyme Activity 12.6 Kinetics of Enzyme Deactivation 12.7 Yields in Cell Culture 12.8 Cell Growth Kinetics 12.9 Growth Kinetics with Plasmid Instability 12.10 Production Kinetics in Cell Culture 12.11 Kinetics of Substrate Uptakein Cell Culture 12.12 Effect of Culture Conditions on Cell Kinetics 12.13 Determining Cell Kinetic Parameters from Batch Data 12.14 Effect of Maintenance on Yields 12.15 Kinetics of Cell Death 12.16 Metabolic Engineering Summary of Chapter 12 References Suggestions for Further Reading Chapter 13. Heterogeneous Reactions 13.1 Heterogeneous Reactions in Bioprocessing 13.2 Concentration Gradients and Reaction Rates in Solid Catalysts 13.3 Internal Mass Transfer and Reaction 13.4 The Thiele Modulus and Effectiveness Factor 13.5 External Mass Transfer 13.6 Liquid–Solid Mass Transfer Correlations 13.7 Experimental Aspects 13.8 Minimising Mass Transfer Effects 13.9 Evaluating True Kinetic Parameters 13.10 General Comments on Heterogeneous Reactions in Bioprocessing Summary of Chapter 13 References Suggestions for Further Reading Chapter 14. Reactor Engineering 14.1 Bioreactor Engineering in Perspective 14.2 Bioreactor Configurations 14.3 Practical Considerations for Bioreactor Construction 14.4 Monitoring and Control of Bioreactors 14.5 Ideal Reactor Operation 14.6 Sterilisation 14.7 Sustainable Bioprocessing Summary of Chapter 14 References Suggestions for Further Reading Appendices APPENDIX A. Conversion Factors APPENDIX B. Ideal Gas Constant APPENDIX C. Physical and Chemical Property Data APPENDIX D. Steam Tables APPENDIX E. Mathematical Rules APPENDIX F. U.S. Sieve and Tyler Standard Screen Series UR - https://books.google.co.in/books?id=wZSylDhgEXMC&printsec=frontcover&dq=bioprocess+engineering+principles+by+doran&hl=en&sa=X&ved=0ahUKEwj3uIHr0eXhAhXDgeYKHfj2AdQQ6AEILjAB#v=onepage&q=bioprocess%20engineering%20principles%20by%20doran&f=false ER -