Handbook of pharmaceutical biotechnology

Chapter 1. Introduction to Biotechnology
Delivery of Recombinant DNA into Expression Vectors
Host or Expression Cells
Development of Recombinant Protein
Hybridoma Technology
Chimerization Process
Chapter 2. Monoclonal Antibodies
Introduction
Abciximab (Reopro®)
Muromonab-CD3 (Orthoclone®)
Basiliximab (Simulect®)
Daclizumab (Zenapax®)
Rituximab (Rituxan®)
Trastuzumab (Herceptin®)
Palivizumab (Synagis®)
Chapter 3. Clotting Factors
Introduction
Recombinant Factor VIII (NovoSeven®)
Factor VIII
Antihemophilic Factor (Recombinant) (Recombinate™)
Antihemophilic Factor (Recombinant) (Kogenate®)
Recombinant, B-Domain Deleted Factor VIII, r-FVIII SQ (Refacto®)
Factor IX rFIX (Benefix®)
Chapter 4. Enzymes and Regulators of Enzyme Activity
Introduction
Alteplase (Activase®)
Reteplase (Retavase®)
Lanoteplase
Tenecteplase
Dornase Alfa (Pulmozyme®)
Chapter 5. Cytokines (Stan G. Louie and Parul Patel)
Introduction
Interleukin 2
Interleukin-11
Interferons
Colony-Stimulating Factors
Platelet-Derived Growth Factor BB
Chapter 6. Anticytokines
Introduction
Interleukin-1 Receptor Antagonist
Tumor Necrosis Factor Soluble Receptor
TNF- Soluble Receptor p55-IgG1 Fusion Protein
Chapter 7. Oligonucleotide and Gene Therapy
Introduction
Oligonucleotide Therapy
ras-Antisense Therapy
Gene Delivery Systems
Current Strategies for Cancer Gene Therapy
Clinical Trials with Gene Therapy