Introduction to Protein Structure (Record no. 46863)

MARC details
000 -LEADER
fixed length control field 03009nam a22001937a 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
020 ## - INTERNATIONAL STANDARD BOOK NUMBER
International Standard Book Number 9780815323051
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Item number BRA-I
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Branden, Carl and Tooze, John
245 ## - TITLE STATEMENT
Title Introduction to Protein Structure
250 ## - EDITION STATEMENT
Edition statement 2nd ed.
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Place of publication, distribution, etc New York
Name of publisher, distributor, etc Garland Science T & F group
Date of publication, distribution, etc 1999
300 ## - PHYSICAL DESCRIPTION
Extent 410p.
500 ## - GENERAL NOTE
General note Part I Basic Structural Principles<br/>1. The Building Blocks<br/>Proteins are polypeptide chains<br/>The genetic code specifies 20 different amino<br/>acid side chains<br/>Cysteines can form disulfide bridges<br/>Peptide units are building blocks of protein<br/>structures<br/>Glycine residues can adopt many different<br/>conformations<br/>Certain side-chain conformations are<br/>energetically favorable<br/>Many proteins contain intrinsic metal atoms<br/>Conclusion<br/>Selected readings<br/>2. Motifs of Protein Structure<br/>The interior of proteins is hydrophobic<br/>The alpha (a) helix is an important<br/>element of secondary structure<br/>The a helix has a dipole moment<br/>Some amino acids are preferred in<br/>a helices<br/>Beta (b) sheets usually have their b strands<br/>either parallel or antiparallel<br/>Loop regions are at the surface of<br/>protein molecules<br/>Schematic pictures of proteins highlight<br/>secondary structure<br/>Topology diagrams are useful for classification<br/>of protein structures<br/>Secondary structure elements are connected<br/>to form simple motifs<br/>The hairpin b motif occurs frequently in<br/>protein structures<br/>The Greek key motif is found in antiparallel<br/>b sheets<br/>The b-a-b motif contains two parallel<br/>b strands<br/>Protein molecules are organized in a structural<br/>hierarchy<br/>Large polypeptide chains fold into several<br/>domains<br/>Domains are built from structural motifs<br/>Simple motifs combine to form complex motifs<br/>Protein structures can be divided into<br/>three main classes<br/>Conclusion<br/>Selected readings<br/>3. Alpha-Domain Structures<br/>Coiled-coil a helices contain a repetitive<br/>heptad amino acid sequence pattern<br/>The four-helix bundle is a common domain<br/>structure in a proteins<br/>Alpha-helical domains are sometimes large<br/>and complex<br/>The globin fold is present in myoglobin and<br/>hemoglobin<br/>Geometric considerations determine<br/>a-helix packing<br/>Ridges of one a helix fit into grooves of an<br/>adjacent helix<br/>The globin fold has been preserved during<br/>evolution<br/>The hydrophobic interior is preserved<br/>Helix movements accommodate interior<br/>side-chain mutations<br/>Sickle-cell hemoglobin confers resistance<br/>to malaria<br/>Conclusion<br/>Selected readings<br/>4. Alpha/Beta Structures<br/>Parallel b strands are arranged in barrels<br/>or sheets<br/>Alpha/beta barrels occur in many different<br/>enzymes<br/>Branched hydrophobic side chains dominate<br/>the core of a/b barrels<br/>Pyruvate kinase contains several domains,<br/>one of which is an a/b barrel<br/>Double barrels have occurred by gene<br/>fusion<br/>The active site is formed by loops at one<br/>end of the a/b barrel
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Protein,
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://dasher.wustl.edu/bio5357/readings/branden-tooze-intro-protein-structure.pdf">https://dasher.wustl.edu/bio5357/readings/branden-tooze-intro-protein-structure.pdf</a>
901 ## - LOCAL DATA ELEMENT A, LDA (RLIN)
Acc. No. 15AIB
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Reference Book
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Collection code Home library Current library Shelving location Date acquired Source of acquisition Cost, normal purchase price Inventory number Total Checkouts Full call number Barcode Date last seen Uniform Resource Identifier Price effective from Koha item type
    Dewey Decimal Classification   Not For Loan Reference Amity Central Library Amity Central Library AIB 20/03/2023 Standard Book Agency 8251.20 SBA/12653 Dt.31/03/2021   572.633BRA-I 15AIB 20/03/2023 https://epgp.inflibnet.ac.in/ 20/03/2023 Reference Book
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